Can You Trust A Company That Has Such Scant Regard For Children’s Lives?


“…In terms of whether we think Seroxat should be made available to children, absolutely…”

(Said Alastair Benbow : Glaxo’s former Head of European Clinical Psychiatry in an Interview With Shelley Jofre- from BBC Panorama 2002)

http://news.bbc.co.uk/2/hi/health/2976498.stm

(BBC 2003)

“Seroxat has been available in the UK for the past 13 years. Approximately four million prescriptions for the drug were issued in the past year.

An estimated 8,000 patients under the age of 18 have been treated with the drug over the last 12 months.

This is despite the fact that the drug is not licensed for use in under 18s. However, doctors can prescribe Seroxat to people in this age group if they believe it is in the patient’s best interest.

But the review, by the Committee on Safety of Medicines (CSM), has concluded the drug should no longer be prescribed to children.

Its experts said the risks outweighed the potential benefits. Their decision was based on new research provided by GlaxoSmithKline, the makers of Seroxat.


 

http://www.independent.co.uk/news/business/news/glaxosmithkline-pays-3bn-for-illegally-marketing-depression-drug-7904555.html

GlaxoSmithKline, the UK’s largest drug maker, tricked and bribed doctors into prescribing children with dangerous antidepressants, it was revealed last night.

The company will pay $3bn (£1.9bn) to settle a slew of charges in the US after admitting a multi-year criminal scheme to hide unhelpful scientific evidence, manipulate articles in medical journals and lavish gifts on sympathetic doctors.

The drug at the centre of the scheme, the blockbuster pill Paxil, which is branded Seroxat in Britain, has since been banned for use by children because it can make them suicidal.

Company managers, all the way up to GSK’s chief executive, Sir Andrew Witty, will have their pay and bonuses clawed back if there is any further wrongdoing, under the terms of a wide-ranging settlement with the Department of Justice.

GSK admitted illegally marketing several of its drugs for uses that had not been approved by safety regulators, and documents released by the Justice Department detailed the luxurious conferences in exotic climes where paid-for scientific speakers hyped up the conclusions of dubious academic papers.

GSK held eight “Paxil forum” events in Puerto Rico, Hawaii and California, where hundreds of doctors were treated to snorkelling, horse-riding, sailing, deep-sea fishing, balloon rides and spa treatments, and given an “honorarium” of $750 in cash. The company knew it was worth paying for these kinds of boondoggles; it monitored the doctors who attended and found they significantly increased prescriptions of Paxil in the months after the event.

Paxil, once GSK’s best-selling drug, was never approved for use by children but because doctors were free to use their discretion, the company had a strong incentive to steer the medical profession to scientific studies that suggested it might be helpful to under-18s diagnosed with depression. Those studies were paid for by GSK itself. Sales reps for Paxil even called on paediatricians to highlight the studies.

The company pleaded guilty to criminal charges related to the marketing of Paxil for use by children between 1999 and 2003, when it:

* failed to reveal the existence of two scientific studies that showed the drug was ineffective in treating childhood depression;

* cut out important caveats to the conclusion of a third study which suggested it may improve a small number of symptoms in children;

* over-hyped the conclusions of that study, after it was published, in marketing materials at conferences and distributed to doctors.

GSK also illegally promoted Wellbutrin, another antidepressant, for the treatment of adult impotence, obesity and attention deficit, according to its guilty plea yesterday.

James Cole, US Deputy Attorney General, said: “We are determined to stop practices that jeopardise patients’ health, harm taxpayers and violate the public trust – and this historic action is a clear warning to any company that chooses to break the law.”

The settlement – $1bn in criminal fines, $2bn in civil penalties – also resolved claims that GSK billed government-run healthcare plans too much for many drugs.

“Whilst these originate in a different era for the company, they cannot and will not be ignored,” Sir Andrew said. “On behalf of GSK, I want to express our regret and reiterate that we have learnt from the mistakes that were made.”

GSK had already set aside more than $3bn to cover the costs of the settlement, and its shares rose 1.75 per cent yesterday, more than the overall market, to reflect the end of a period of uncertainty.

The company will submit to a “corporate integrity agreement” with the US government that involves a shake-up of its remuneration plan for senior managers and executives, and reflects changes already made to sales practices. The 100 top managers in the US business and the executive board will have to set aside a portion of their annual pay for three years in case they are found to be complicit in future wrongdoing, and the company will be able to claw back up to three times their annual bonus and long-term incentive pay.

Danger Drug: suicides linked to antidepressants

Sara Carlin, 18, was a talented student who dreamt of becoming a doctor, only for her to take her own life back in 2007, a little over a year after being prescribed anti-depressants. She was found hanging in the basement of her family home in Oakville, Canada.

The country’s health authorities put out warnings in 2003 and 2004 that prescribing newer antidepressants such as Paxil to teenagers could lead to behavioural changes and self-harm, but Sara brushed off her mother’s attempts to warn her off such drugs, saying her doctor had said they would lift her mood.

Colin Whitfield, 56, died just two weeks after he began taking the antidepressant drug Seroxat. The retired Welsh teacher was found in the garden shed of the family home having slit his own wrists in 2002.

At the inquest the coroner said that he had “grave concerns that this is a dangerous drug that should be withdrawn until detailed national studies are undertaken.”

Kathryn, Colin’s wife of more than 30 years, said that she had noticed a profound change in her husband’s behaviour once he started taking Seroxat, and the drug may have contributed to his unexpected suicide. “It didn’t fit the picture of who he was and we have no doubt that it was the drug that caused him to do it. He was a very caring, very protective father,” she said.


https://en.wikipedia.org/wiki/Study_329

Study 329

From Wikipedia, the free encyclopedia
Study 329
Paxil, June 2003.jpg

Paroxetine, sold as Paxil and Seroxat
Study type Eight-week, double-blind, randomized clinical trial comparing paroxetine with imipramine and placebo in adolescents with major depressive disorder
Dates 1994 to 1998
Locations 10 centres in the United States, two in Canada
Lead researcher Martin Keller, then professor of psychiatry and human behavior, Brown University
Funding SmithKline Beecham, now GlaxoSmithKline
Protocol “Study drug: BRL29060/Paroxetine (Paxil)”, SmithKline Beecham, 20 August 1993, amended 24 March 1994.
Published 2001
Article Martin B. Keller, et al, “Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial”, Journal of the American Academy of Child and Adolescent Psychiatry, 40(7), July 2001, pp. 762–772. PMID 11437014

Study 329 was a clinical trial conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant marketed as Paxil and Seroxat, in treating depressed teenagers.[1] The trial was funded by the British pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline (GSK), which released paroxetine in 1991. The drug made $11.6 billion between 1997 and 2006.[2]

Led by Martin Keller, then professor of psychiatry at Brown University, study 329 became controversial because the article that reported the trial results – in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) in 2001 – was ghostwritten by a PR firm hired by the drug company and downplayed the trial’s negative findings.[3]

The study had failed to show efficacy for paroxetine in adolescent depression, something SmithKline Beecham acknowledged internally in 1998.[n 1] In addition there had been more examples of suicidal thinking and behaviour in the group taking paroxetine.[n 2] Although the article included these negative results, it did not account for them in its conclusion. On the contrary, it concluded that paroxetine is “generally well tolerated and effective for major depression in adolescents.”[7] The company relied on the article to promote paroxetine for off-label use in teenagers.[n 3]

In 2003 Britain’s Medicines and Healthcare Products Regulatory Agency (MHRA) analysed this and other GSK trials, and concluded there was no evidence of efficacy and a clear increase in suicidal behaviour.[n 4] The next month the MHRA and US Food and Drug Administration (FDA) advised doctors not to prescribe paroxetine to the under-18s.[10] The MRHA launched a criminal inquiry into GSK’s conduct, but announced in 2008 that there would be no charges.[11]

In 2004 New York State Attorney Eliot Spitzer sued GSK for having withheld the data,[12] and in 2012 the US Justice Department fined the company $3 billion, including a sum for withholding data on paroxetine, unlawfully promoting it for the under-18s, and preparing a misleading article about study 329.[n 5] The JAACAP article on study 239 was never retracted.[14] The journal’s editors say the negative findings are included in a table, and that therefore there are no grounds to withdraw it.[15]

Contents

Clinical trial

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Funded by SmithKline Beecham, study 329 was an eight-week, double-blind, randomized clinical trial conducted in 12 university or hospital psychiatric departments in the United States and Canada between 1994 and 1997.[1][16] The study compared paroxetine, a selective serotonin reuptake inhibitor marketed as Paxil and Seroxat, with imipramine, a tricyclic antidepressant marketed as Tofranil, in teenagers (aged 12–18) with a diagnosis of major depressive disorder at least eight weeks in duration.[1] Martin Keller, then professor of psychiatry at Brown University, had proposed the trial to the company in 1992 as the largest study until then to examine the efficacy of SSRIs in children.[7] The trial’s protocol described two primary and six secondary outcomes by which it would measure efficacy.[17][18]

After a screening phase from April 1994, 275 male and female patients were randomly assigned paroxetine, imipramine or placebo (an inert pill).[19] Of the 275, 93 were given paroxetine, 95 imipramine and 89 placebo. The paroxetine group were given 20 mg daily for four weeks, rising to 30 mg at week five and 40 mg at week six if the clinician thought it appropriate.[20] One hundred and ninety completed the trial.[21] The last study visit was in May 1997 and the blind was broken in October.[17]

The results showed that, according to the eight outcomes Keller had first specified, paroxetine was no more effective than placebo. According to Melanie Newman, writing for the BMJ, “[t]he drug only produced a positive result when four new secondary outcome measures, which were introduced following the initial data analysis, were used instead. Fifteen other new secondary outcome measures failed to throw up positive results.”[n 6][17]

In addition, 11 subjects on paroxetine, compared to five on imipramine and two on placebo, experienced serious adverse events (SAE), including behavioral problems and emotional lability. The researchers defined an event as an SAE if it resulted in hospitalization, involved suicidal gestures, or was regarded as serious by the subject’s doctor. In the 93 taking paroxetine, the SAEs consisted of one subject experiencing headache while tapering off, and 10 experiencing psychiatric problems. Seven of the ten were hospitalized. Two of the ten experienced worsening depression, two conduct problems such as aggression, one euphoria, and five emotional lability, including suicidal ideation and behaviour. Of the 95 patients on imipramine and the 89 on placebo, one in each group experienced emotional lability.[22][n 2] The article in JAACAP later concluded that, of the 11 patients who experienced SAEs, “only headache (1 patient) was considered by the treating investigator to be related to paroxetine treatment.”[22]

1998 SmithKline Beecham position paper

The results from study 329 were “insufficiently robust to support a label change,” according to the company in 1998.[4]

In October 1998 the neurosciences division of SmithKline Beecham’s Central Medical Affairs (CMAT) department distributed a position paper, “Seroxat/Paxil Adolescent Depression: Position piece on the phase III clinical studies.” The paper discussed studies 329 and 377.[4] The latter was a 12-week trial comparing paroxetine and placebo in teenagers from 1995 to 1998 in Europe, Canada, South America, South Africa and the United Arab Emirates.[n 7]

The paper explained that the company had decided not to submit 329 and 377 trial data to regulators, and discussed how to “effectively manage the dissemination of these data in order to minimise any potential negative commercial impact.”[7] An attached memo said the results were disappointing and would not support a label claim that paroxetine could be used to treat adolescents: “The best that could have been achieved was a statement that, although safety data was reassuring, efficacy had not been demonstrated.”[24] The paper said: “it would be commercially unacceptable to include a statement that efficacy had not been demonstrated, as this would undermine the profile of paroxetine.”[4]

It stated that study 329 had shown “trends in efficacy in favour of Seroxat/Paxil across all indices of depression … [but had] failed to demonstrate a statistically significant difference from placebo on the primary efficacy measures.” Study 377 had shown a high placebo response rate and had “failed [to] demonstrate any separation of Seroxat/Paxil from placebo.” The company decided to publish study 329 but not 377, and not to submit either trial to the regulators, because they were “insufficiently robust to support a label change” for adolescent use.”[4]

The document was leaked during a lawsuit and first published by the Canadian Medical Association Journal in March 2004. In response a GSK spokesperson said that “the memo draws an inappropriate conclusion and is not consistent with the facts … GSK abided by all regulatory requirements for submitting safety data. We also communicated safety and efficacy data to physicians through posters, abstracts, and other publications.”[7]

JAACAP article

Authorship

Although the article in JAACAP named 22 physicians or other researchers, led by Martin Keller, it had been written by Scientific Therapeutics Information (STI), a PR company in Springfield, New Jersey, specializing in communications for the pharmaceutical industry.[25] STI had worked with SmithKline Beecham on its promotion of paroxetine for years.[n 8] In April 1998 Sally K. Laden and John A. Romankiewicz of STI sent SmithKline Beecham an estimate of $17,250 to work on six drafts of the study 329 paper, including the final draft, to cover the period up to March 1999. The sum was payable in installments: $8,500 upon initiation, $5,125 after draft three, and $3,625 upon submission to the journal.[25][27] The first draft was ready by December 1998.[28]

STI planned to submit the article to the Journal of the American Medical Association (JAMA). The estimate covered all writing, editing, library research, copy editing, art work and coordination with the phsyicians and others who would be named as authors. Martin Keller would be listed as the main author.[25] SmithKline Beecham documents show that Laden and STI coordinated the entire publication process, including writing the cover letter to the journal that published the article, JAACAP, which she sent to Keller with the instruction that he transfer it to his own letterhead.[29][30]

Publication

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GlaxoSmithKline global headquarters, Brentford, west London

The article was first submitted to JAMA, which rejected it in November 1999. Concerns cited by JAMA reviewers included that “the main finding of the study is the high placebo response rate.” They also suggested that the named authors confirm they had been “granted full access to the data set to verify the accuracy of the report.”[31]

Early drafts of the paper for JAMA did not mention the serious adverse events (SAEs). A SmithKline Beecham scientist, James McCafferty, added a paragraph about these in July 1999, adding that 11 patients on paroxetine had experienced SAEs, against two on placebo: “worsening depression, emotional lability, headache, and hostility were considered related or possibly related to treatment.”[32] This was changed in the final draft to: “Of the 11 patients, only headache (1 patient) was considered by the treating investigator to be related to paroxetine treatment.”[22][32]

In December 1999 Laden submitted the rewritten paper to JAACAP, led at the time by editor-in-chief Mina K. Dulcan. According to Melanie Newman in the BMJ, JAACAP’s reviewers wrote that the results did not “clearly demonstrate efficacy for paroxetine,” and asked whether, because of the high placebo response rate, SSRIs should be regarded as first-line therapy.[33] JAACAP accepted the article in January 2001,[34] and published it in July. Twenty-two researchers were listed, led by Martin Keller, including James P. McCafferty of GSK, though his company connection was not included. Of STI and Sally Laden, the published article said only: “Editorial assistance was provided by Sally K. Laden, M.S.”[1]

The abstract concluded: “Paroxetine is generally well tolerated and effective for major depression in adolescents.”[1] McCafferty’s paragraph about worsening depression and emotional lability possibly being related to the treatment had been removed. The only SAE attributed to paroxetine in the JAACAP article was in one patient who had reported headache.[22][32] The article continued: “Because these serious adverse events were judged by the investigator to be related to treatment in only 4 patients (paroxetine, 1; imipramine, 2; placebo, 1), causality cannot be determined conclusively.” It concluded: “The findings of this study provide evidence of the efficacy and safety of the SSRI, paroxetine, in the treatment of adolescent depression.”[35]

2001 GlaxoSmithKline sales memo

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Over two million prescriptions for paroxetine were written for children or adolescents in the US in 2002.[36]

GSK used the JAACAP article to promote paroxetine to doctors for use in their teenage patients. The drug had not been approved for use in adolescents. Drug companies are prohibited from promoting drugs for unapproved uses, but doctors are permitted to prescribe drugs for what is known as off-label use. In the UK 32,000 prescriptions were written for children and adolescents in 1999,[37] and in the US that figure rose to 2.1 million in 2002, earning GSK $55 million.[36]

In August 2001 Sally Laden, the article’s author, arranged for GSK to buy 500 reprints of the article; 300 were for Keller and 200 for Zachary Hawkins of GSK’s Paxil Product Management team, to be distributed to the company’s neuroscience sales force.[38] On 16 August Hawkins sent a memo about study 329 to “all sales representatives selling Paxil” calling study 329 a “‘cutting-edge,’ landmark study,” and stating that “Paxil demonstrates REMARKABLE Efficacy and Safety in the treatment of adolescent depression.”[8]

The memo said that paroxetine was “significantly more effective than placebo” on certain outcomes. Hawkins added: “Paxil was generally well tolerated in this adolescent population and most adverse events were not serious. The most common adverse events occurred at rates that were similar to rates in the placebo group.”[8]

MHRA criminal inquiry

BBC Panorama

Scottish reporter Shelly Jofre presented four investigative programmes on paroxetine for BBC Panorama between 2002 and 2007, including one on study 329, Secrets of the Drug Trials (2007).[39] In November 2002 Britain’s Medicines and Healthcare Products Regulatory Agency (MHRA) called a meeting with GSK to discuss the safety issues Jofre had raised in the first programme, The Secrets of Seroxat (2002). The MHRA asked GSK about its clinical trials in children. GSK was planning to apply for pediatric indications for paroxetine in June 2003.[40] At the time the Summary of Product Characteristics for paroxetine in Europe said that its use in children was “not recommended as safety and efficacy have not been established in this population.”[41] According to the MHRA, “GSK did not raise any concern about lack of efficacy or adverse reactions in the clinical trials in the paediatric population at that meeting.”[40]

GSK briefing paper

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GSK handed the MHRA a briefing paper on its clinical trials on paroxetine and children in May 2003.[42]

The MHRA’s Committee on the Safety of Medicines (CSM) set up an Expert Working Group in February 2003 to investigate SSRIs and safety.[43] In preparation for its first meeting, the MHRA met GSK on 21 May 2003 to make sure GSK had supplied all information relevant to paroxetine and safety, and to discuss Jofre’s second Panorama programme about paroxetine, Emails from the edge (2003), which had aired on 11 May.[42]

During the programme, Alistair Benbow, head of European psychiatry for GlaxoSmithKline, told Jofre: “We have been asked by the regulatory authorities to provide all our information related to suicides and I can tell you the data that we provide to them clearly shows no link between Seroxat and an increased risk of suicide – no link.”[44]

Toward the end of the 21 May meeting with the MHRA, GSK handed out a briefing paper dated 20 May.[42] The paper included data from nine clinical trials GSK had conducted on paroxetine and children between 1994 and 2002, including study 329.[n 9] It concluded that “analysis of the safety data demonstrates that paroxetine is generally well tolerated by paediatric patients …,” but suggested a label change to the effect that efficacy had not been established in children with major depressive disorder, and that adverse reactions could include hyperkinesia, hostility, emotional lability and agitation. The paper said these had occurred around twice as much in the paroxetine group than in those taking placebo.[46]

By “emotional lability,” the document referred in particular to suicidal thoughts and behaviour. Of 20 reports of adverse events in the paroxetine groups, 12 had been suidical thoughts or suicide attempts (none successful), three self-mutilation and five general emotional lability. There had been eight adverse events in the patients taking placebo, of which four were suicidal thoughts or behaviour, one self-mutilation and three emotional lability. The author also suggested a label change regarding withdrawal symptoms, which s/he said had occurred with paroxetine at roughly twice the rate of placebo.[46]

MHRA response

The MHRA issued an advisory to physicians in June 2003 not to prescribe paroxetine to the under-18s, and launched a criminal inquiry.[47][3]

According to the MHRA, the data provided “robust evidence” of a causal link between paroxetine and suicidality, and no evidence that paroxetine was effective in treating depression in children.[9] Alasdair Breckenridge, chair of the MRHA at the time, said it caused “a very dramatic change in our thinking about Seroxat and children.”[48]

GSK was asked to submit the full clinical data, which they did on 27 May. The MHRA wrote: “It was only when the trials were analysed together that the safety issue became apparent.”[9] The analysis suggested an increased rate of suicidal thinking and behaviour of 3.4 percent on paroxetine versus 1.2 percent on placebo.[49] The committee concluded that the risks outweighed the benefits,[50] and on 10 June issued an advisory to physicians not to prescribe paroxetine to the under-18s.[47] The US Food and Drug Administration (FDA) followed suit nine days later.[10]

The MRHA launched a criminal inquiry in October 2003 into GSK’s conduct. This was based on two concerns, namely the length of time between the end of the trials and GSK’s passing the safety concerns to the MHRA, and also the manner in which the material had been handed over. Rather than alerting the MHRA of a risk, GSK had supplied the data in relation to an application to extend the indications of paroxetine to children. The MHRA deemed this inappropriate for an urgent safety concern because of the length of time such applications can take.[51] Medical ethicists Linsey Goey and Emily Jackson write that the 1998 SmithKline Beecham position paper, in which the company said it had decided not to show studies 329 and 377 to regulators,[4] represented a prima facie breach of the Medicines Act 1968 and Medicines for Human Use Regulations, which required pharmaceutical companies to pass to the regulator trial data with safety and efficacy implications.[52]

The MRHA reviewed one million documents in the course of the inquiry.[53] After a four-year investigation, government lawyers advised that the law was not clear enough to prosecute the company, and the MHRS announced in March 2008 that there would be no charges.[11][54] In October 2008 the Medicines for Human Use (Marketing Authorisations Etc.) Regulations 1994 were amended to prevent a repetition of the case.[55]

FDA-mandated review

In March 2004 the FDA mandated that drug companies review the use of their SSRIs in children. In 2006 GSK researchers published a review of five of their trials involving paroxetine and adolescents or children, including study 329 and the unpublished 377. They wrote that suicidal thinking or behaviour had occurred in 22 of 642 patients on paroxetine (3.4 percent) against 5 of 549 on placebo (0.9 percent). The article concluded that: “Adolescents treated with paroxetine showed an increased risk of suicide-related events. … The presence of uncontrolled suicide risk factors, the relatively low incidence of these events, and their predominance in adolescents with MDD make it difficult to identify a single cause for suicidality in these pediatric patients.[56]

Legal action

Overview

Paroxetine attracted sales of $11.6 billion from 1997 to 2006, including $2.12 billion in 2002, the year before it lost its patent. By 2009 GSK had paid almost $1 billion to settle paroxetine-related lawsuits related to 450 suicides, withholding data, as well as addiction, antitrust and other claims. An additional 600 unsettled claims related to birth defects.[2] The lawsuits produced thousands of internal company documents, some of which entered the public domain.[17] These formed the basis of investigative pieces about paroxetine by Alison Bass for The Boston Globe, developed into a book, Side Effects (2008), and four programmes by Shelley Jofre for BBC Panorama beginning in 2002, including one about study 329.[39]

People v. GlaxoSmithKline

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Eliot Spitzer filed a lawsuit against GSK in 2004.

In June 2004 New York State Attorney Eliot Spitzer filed a lawsuit against GSK in the New York State Supreme Court for having withheld clinical trial data about paroxetine, including from study 329.[57] GSK denied any wrongdoing and said it had disclosed the data to regulators, and to physicians at medical conventions and in other ways.[58]

GSK settled the case in August 2004, agreeing to pay $2.5 million, make its trial data about paroxetine and children available on its website, and establish a clinical trial register that would host summaries of all company-sponsored trials going back to 27 December 2000. By October 2004 other drug companies, including Pfizer, Eli Lilly and Merck, had agreed to create their own registers.[59] In 2013 GSK joined AllTrials, a British campaign to have all clinical trials registered and the results reported.[60]

United States v. GlaxoSmithKline

In October 2011 the US Department of Justice filed a lawsuit under the False Claims Act accusing GSK of promoting drugs for unapproved uses, failing to report safety data, reporting false prices to Medicaid, and paying kickbacks to physicians in the form of gifts, trips and sham consultancy fees. The complaint included preparing the JAACAP article about study 329, exaggerating paroxetine’s efficacy while downplaying the risks, and using the article to promote the drug for adolescent use, which was not approved by the FDA.[13]

GSK pleaded guilty in 2012 and paid a $3 billion settlement, including a criminal fine of $1 billion. The fine included an amount for “preparing, publishing and distributing a misleading medical journal article that misreported that a clinical trial of Paxil demonstrated efficacy in the treatment of depression in patients under age 18, when the study failed to demonstrate efficacy.”[13]

Call for retraction

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Child psychiatrist Jon Jureidini called for the JAACAP article to be retracted.[61]

Child psychiatrist Jon Jureidini of the Women’s and Children’s Hospital in Adelaide and Ann Tonkin of the University of Adelaide asked JAACAP in 2003 to retract the study 329 paper.[62][n 10]

In 2005 philosopher Leemon McHenry complained to the journal that Keller and some of the other researchers named as authors had worked for GSK, but had not declared their conflict of interest.[61] Keller had acted as a consultant for several drug companies. The Boston Globe reported in 1999 that he had earned $500,000 the previous year from consultancy work, which, the newspaper said, he did not disclose to the journals that published his work or to the American Psychiatric Association.[64]

Jureidini and McHenry called again for the paper’s retraction in 2009. Editor-in-chief Andrés Martin replied that there was no justification for retraction, and that the journal had “conformed to the best publication practices prevailing at the time.”[61] In 2013 Jureidini asked GSK’s CEO Andrew Witty to request retraction.[65][66] In July that year Jureidini announced his intention to produce a new write-up of study 329 in accordance with the RIAT initiative (restoring invisible and abandoned trials).[67][66]

Anti-depressants and suicidality in children

Whether antidepressants increase the risk of suicide is controversial. In 2007 the FDA required that all anti-depressants include a boxed warning of an increased risk of suicidal thoughts and behaviour in young adults (18–24) during the first one to two months of treatment.[68][n 11] A 2012 Cochrane review on the use of SSRIs in children and adolescents concluded that there is evidence of an increased suicide risk in patients treated with antidepressants. It added: “However, given the risks of untreated depression in terms of completed suicide and impacts on functioning, if a decision to use medication is agreed, then fluoxetine might be the medication of first choice given guideline recommendations.”[n 12]

See also

References

Notes

  • SmithKline Beecham, October 1998: “Study 329 (conducted in the US) showed trends in efficacy in favour of Seroxat/Paxil across all indices of depression. However, the study failed to demonstrate a statistically significant difference from placebo on the primary efficacy measures.”[4]FDA to GlaxoSmithKline, 21 October 2002: “We agree that … the results from Studies 329, 377, and 701 failed to demonstrate the efficacy of Paxil in pediatric patients with MDD. Given the fact that negative trials are frequently seen, even for antidepressant drugs that we know are effective, we agree that it would not be useful to describe these negative trials in labeling.”[5]MHRA, 6 March 2008: “The first trial conducted by SKB, trial number 329, failed to show that Seroxat was effective in treating major depressive disorder in children. … None of these trials demonstrated efficacy for Seroxat in treating pediatric MDD.”[6]
  • Wayne Kondro, Barbara Sibbald, Canadian Medical Association Journal, 2004: “Among the 93 adolescents taking Seroxat, there were 5 serious cases of ’emotional lability’ (e.g., suicidal ideation/ gestures). Among the 95 patients taking the comparison treatment, imipramine (Tofranil), there was 1 such case, and among the 89 subjects receiving placebo there was also 1. According to the article, only 1 serious adverse event — headache in 1 patient — was considered by the treating investigator to be related to paroxetine treatment.”[7]
  • In August 2001, a month after publication, a member of GSK’s Paxil Product Management team sent a memo to “all sales representatives selling Paxil” calling study 329 a “‘cutting-edge,’ landmark study,” and stating that “Paxil demonstrates REMARKABLE Efficacy and Safety in the treatment of adolescent depression.”[8]
  • MRHA, 6 March 2008: “The significance of the data provided in the GSK briefing document was that they represented robust evidence from controlled studies of a causal association between an SSRI and suicidal behaviour. It had previously been argued by some manufacturers that a causal link could not be drawn between suicidality and SSRIs because no link was evident from (adult) clinical trial data. On examination of the full clinical trial data in children submitted by GSK urgently on 27 May 2003 in response to requests from the Agency, it became clear that the evidence base for the safety concern of an increased risk of suicidal behaviour was derived from pooled analysis of all the trials (a meta-analysis). It was only when the trials were analysed together that the safety issue became apparent. These trials had been conducted over a number of years and some had been published in part, however the publications gave an incomplete and partial picture of the full data. Importantly, the trials conducted in a range of conditions in children and adolescents failed to demonstrate that Seroxat was effective in the treatment of depressive illness.”[9]
  • “The United States alleges that, among other things, GSK participated in preparing, publishing and distributing a misleading medical journal article that misreported that a clinical trial of Paxil demonstrated efficacy in the treatment of depression in patients under age 18, when the study failed to demonstrate efficacy.”[13]
  • Melanie Newman, BMJ, 2010: “Study 329’s results showed that paroxetine was no more effective than the placebo according to measurements of eight outcomes specified by Martin Keller, professor of psychiatry at Brown University, when he first drew up the trial.“Two of these were primary outcomes: the change in total Hamilton Rating Scale (HAM-D) score, and the proportion of ‘responders’ at the end of the eight week acute treatment phase (those with a ≥50% reduction in HAM-D or a HAM-D score ≤8). The drug also showed no significant effect for the initial six secondary outcome measures.“The drug only produced a positive result when four new secondary outcome measures, which were introduced following the initial data analysis, were used instead. Fifteen other new secondary outcome measures failed to throw up positive results.”[15]
  • Study 377 was conducted in 33 centres in Europe (Belgium, Holland, Italy, Spain, UK), Canada, South America (Argentina and Mexico), South Africa and the United Arab Emirates.[23]
  • In 1993, for example, STI sent a proposal to GSK for a meeting between its psychiatrist advisory board and Paxil advisory board in the Ritz Carlton Hotel in Palm Beach, Florida.[26]
  • GSK gave the MHRA data from nine clinical trials it had conducted between April 1994 and September 2002: study 704 (on paroxetine and obsessive-compulsive disorder or OCD); study 676 (social anxiety disorder); studies 329, 377 and 701 (major depressive disorder or MDD); studies 453 and 329 continuation, study 716 (OCD, MDD); and study 715 (OCD, MDD).[45]
  • The Committee on Publication Ethics states that journal editors should consider retracting an article if, inter alia, “they have clear evidence that the findings are unreliable, either as a result of misconduct … or honest error.”[63]
  • “Medication guide Paxil”, FDA, June 2014: “Paxil and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.”

Sarah E. Hetrick, et al, 2012: “Caution is required in interpreting the results given the methodological limitations of the included trials in terms of internal and external validity. Further, the size and clinical meaningfulness of statistically significant results are uncertain. However, given the risks of untreated depression in terms of completed suicide and impacts on functioning, if a decision to use medication is agreed, then fluoxetine might be the medication of first choice given guideline recommendations. Clinicians need to keep in mind that there is evidence of an increased risk of suicide-related outcomes in those treated with antidepressant medications.”[69]

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2 comments

  1. kiwi

    What i find unacceptable is the medication guide in 2014 is totally silent on sexual damage yet Healy said at the 2015 Yale Symposium that within one week of starting an ssri a person can be sexually damaged and it can last forever. Often the damage is not revealed until a person goes off the drug.

    Also, i find unacceptable in the guide is the fact that GSK are still not making it clear these drugs are the cause of suicidality continuing to confuse by blaming the person and not the poison.

    Bass in her book Side effects says this regarding those who think the black box warning caused suicides to go up;
    Consider this, in December 2006, the FDA held an advisory meeting to consider new findings that young adults between 18 and 25 who took Paxil/paroxetine and eight other antidepressants were significantly more likely than those on placebo to report a suicide attempt, just as the research on children and adolescents had shown. At that hearing, opponents of the black box warnings on SSRI cited preliminary results from a study showing what appear to be a correlation between an uptick in national suicide rates among adolescents and a drop in the prescription of SSRIs among this age group. Several psychiatrists pointed to the apparent correlation as proof that the publicity over the SSRIs in the black box warnings had scared physicians from prescribing these drugs. The lack of treatment, the psychiatrist argued, may have prompted more youngsters to kill themselves.
    However when this finding was published in the September 2007 issue of the American Journal of psychiatry, it was roundly criticised as being erroneous. The number of suicides among adolescents under the age of 19 did indeed climb about 14% (from 1737 to 1,985) between 2003 and 2004, according to statistics from the centres for disease control and prevention. The number of prescriptions for SSRIs among adolescents, however, remained essentially unchanged from 2003 to 2004 (prescription usage didn’t decline until after 2004). Thus the FDA’s black box warnings cannot be blamed for the apparent increase in suicides among adolescents the year before.

    This discrepancy in the data was not mentioned at the December 2006 FDA hearing.

    Nor was it disclosed that an SSRI maker (Pfizer) paid $30,000, the cost of obtaining prescription data for the AJP study, or that two lead authors of the study have financial conflicts of interest: Robert Gibbons served as an expert witness for Wyeth pharmaceuticals (the maker of Effexor/venlafaxine a SNRI), and Dr J John Mann a professor of psychiatry at Columbia University, has been a paid consultant to at least two SSRI makers, GSK and Pfizer.
    Other psychiatric researchers say that the latest upturn in suicide rates does not mean anything, given the small numbers involved and the tendency of suicide rates to fluctuate from year to year. “People who are specialists in statistics know you have to look at trends over years and years”, said Julie Zito an associate Professor of pharmacy and psychiatry at the University of Maryland, who has published several articles on the subject. “For instance you will see that the overall trend in suicide rates among children and adults has been going down quite a ways before the SSRI s arrived on the scene.”
    In the end the FDA did extend split box warnings on antidepressants to young adults. But it also added language to the labels warning that “depression and certain other psychiatric disorders are themselves associated with the risk of suicide” the FDA’s Thomas Laughren now director of the Division of psychiatry Products, said the new language had been added because of the agency’s concerns about the uptick in suicide rates between 2003 and 2004. Both Zito and Dr Peter Lurie deputy director of the public citizen health research group, say that including language about untreated depression in the black box cautions on antidepressants undermines the whole point of the warning. The important thing is that the risk of suicidal ideation is higher in the treated group than untreated group in randomised controlled trials, and that’s what the warning should be about, Lurie says “whether or not untreated depression also leads to suicidal ideation is misleading and irrelevant. The FDA should not have put in that kind of language because it is intended to confuse.”

    “We know these drugs increase the risk of suicide, in young people and up to the age of 40, according to FDA data, and many suicides have been reported even in healthy people who took the drugs for other reasons. We don’t really know what they do are above the age of 40, because the drug companies have cheated so enormously in their randomised trials, so in the worst case these drugs might increase the risk of suicide in all age groups…… The business model is organised crime.”
    Peter Gotzsche; 2014.

    • truthman30

      To me it seems like a situation has developed similar to the way tobacco companies were eventually forced to concede that tobacco causes cancer etc. It seems to be ‘take them at your own risk’ but on the other hand, we have psychiatrists and doctors pretending that these risks don’t exist with SSRI’s.

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