Seroxat Link 9 : Side Effects Galore : PIL 1996 to 2006

In this post I am going to compare the differences and changes between the current (2006) Seroxat PIL ( Patient Information Leaflet) and the PIL from twelve years ago (1996)

There is an earlier one from 1991 ( But it is sensitive information apparantly and I cannot post about it)

So, I will focus mainly here on some key points from these two PIL’s. You will notice the differences between them and how the side effect profile of seroxat has increased massively in size in a decade, it is really quite remarkable. Just reading the sheer volume of “official” Seroxat side effects added to the 2006 PIL would make anyone feel depressed or anxious… ( not to mention dizzy and nauseous) (My comments will be in brackets in italics after each point)

    PIL 1996


What is “Seroxat”?

Everyone has a substance called Serotonin in their body. Low levels of Serotonin are thought to be a cause of Depression and other related conditions. This medicine works by bringing the levels of serotonin back to normal. ( Unproven pseudoscience nonsense )

Seroxat works by relieving symptoms of depression and any associated anxiety. It also treats obsessions , compulsions and panic attacks. These tablets are not addictive. Most people find that Seroxat does not affect their daily lives . ( Not Classed as Addictive, but does cause Dependence which is Addiction , and does cause withdrawal which is a criteria of physically addictive substances )

The usual dose to treat depression is 20mg a day but your doctor may tell you to take up to 50mg a day.
Some people find that if they suddenly stop taking these tablets they feel dizzy, shaky, sick, anxious, confused or have tingling sensations. They also may have difficulty sleeping, and have vivid dreams when they do sleep. But these symptoms are unusual and generally disappear after a few days. ( never proven to work over 20mg )

If you stop taking your tablets too soon your symptoms may return. Remember you cannot become addicted to Seroxat.
( Symptoms such as withdrawal? You can become addicted to Seroxat )

Does “Seroxat: cause side effects? Any medicine can cause unwanted effects, with Seroxat any side effects are usually mild and go away after a few weeks. The most likely side effect of seroxat is that you might feel slightly sick. When taking Seroxat some people may find they have an upset stomach, a rash, or dry mouth. They may sweat more than usual or feel drowsy but unable to sleep soundly. They may also lose their appetite or become constipated. Men may have difficluty having an erection and may find it difficult to ejaculate. All of these side effects will go away once you stop taking the tablets. ( some of these side effects are permanent)

Patients can occasionalyy feel dizzy, shaky or restless or they may feel faint when they stand up. Very rarely patients may feel fascial, body or muscle spasms or sudden mood changes. ( This is very common, NOT very rare )

Depression is a common illness. At any one time one in 20 people will be suffering from it.
The balance of chemicals in the brain is thought to affect the way we feel. Serotonin is one of these chemicals and also thought to be low in people who are depressed.

It is important that even when you feel better , you continue taking these tablets until your doctor tells you to stop. This will reduce the chance of your depression returning.
( GSK wanted you to take this stuff for a long time)

    PIL 2006


Seroxat treats depression and anxiety disorders. Like all medicines it can have unwanted effects.
It is therfore impotant that you and your doctor weigh up the benefits of treatment against the possible unwanted affects, before starting treatment. ( the risks clearly outweigh the so called “benefits”)

If you stop or miss a does you may get withdrawal affects

If you feel restless and like you cant sit or stand still tell your doctor

Possible Side Effects

Likely to affect up to one in 100 people

Unusual bleeding or bruising

Other possible side effect during treatment

Likey to affect up to 1 and 10 people

Feeling Sick
Change in Sex drive and Sexual Function

Likely to affect up to one in 10 people

Increases of cholestoral in the blood
Lack of appetite
Feeling Dizzy or Shaky ( tremors )
Feeling Agitated
Blurred Vision
Yawning, dry mouth
Weight Gain
Feeling Weak

Likely to affect up to 1 in 100 people

Bried increase or decrease in blood pressure
Lack of movements, Stiffness , shaking or abnormal movements in the mouth and tongue
Skin rashes
Feeling confused
Uritary incontinence

Likely to affect up to one in every 1000 people

Abnormal production of breast mik in both men and women
A slow heartbeat
Effects on the liver showing up in blod tests of your liver function
Panic Attacks
Overactive thoughts and behaviours (mania)
Feeling detatched from yourself ( depersonalization)
Feeling anxious
Pain in the joints or muscles

Likely to affect up to 1 in 10,000 people

Liver problems that make the skin or whites of the eyes go yellow
Fluid or water retention which may cause swelling of the arms and legs
Sensitivity to sunlight
Painful erection of the penis that wont go away
Unexpected bleeding .eg. Bleeding gums , blood in the urine or in vomit or the appearance of unexpected
bruises or borken blood vessels
Some patients have developed buzzing, whistling, ringing or other persistent noise in the ears (tinnitus) when they take seroxat

Seroxat is a treatment for adults with depression and anxiety disorders. It is not fully understood how Seroxat and other SSRI’s work but they may help by increaing the level of serotonin in the brain.
Other medicines or psychotherapy can also treat depression or anxiety.
( Seroxat is a lobotomy in pill form)




  1. Bob Fiddaman

    Seems that the PIL was handwritten by Alistair Benbow doesn’t it?…. that is of course until threats of legal action brought about change.

    “Remember you cannot become addicted to Seroxat”

    Utter bollocks


  2. Pythia

    If you look at drug monographs in publications such as various physician´s drug reference books you will also find that the number of listed side effects, which are by the way many more than in the PILs, you will find that for all SSRIs the number of listed side effects have increased by about ten for every year during the past four or five years. If you go one step further and look up the side effects in other countries you will find that the drug companies don´t list all side effects in all countries. They do everything possible to make their poisons look less harmful than they are. Immoral bastards.

  3. Matthew Holford


    Great effort, mate. I was going to do something similar, but never got my fat arse into gear! Incidentally, for those unfamiliar, the 1996 PIL was the first obligatory patient information. PILs are assessed and approved by the regulator (in the EU, at least), but will always remain the responsibility of the “marketing authorization holder” – GSK, in this case.

    I have no idea what the 1991 PIL says, but I’ll bet there’s even less information on that!


  4. Matthew Holford

    Sorry, one other thing, which I have to include, because it still makes me laugh! The 1998 US PIL (as offered in evidence in Tobin v SKB (the Donald Schell case) has Seroxat down as “significantly more affective [sic] than placebo.” I’m still waiting on GSK and the DoH to come back to me and explain that one!


  5. Jenny

    If you feel restless and can’t sit still (akathisia) tell your doctor…before you kill yourself or someone else. That way they can put you on other brain damaging drugs, and hook you for life.


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